Table 2.
17 Biomarker candidate genes that were selected by three or more.
| Genes | Upregulated or downregulated | Significantly expressed in LUSC or LUAD | Number of algorithms that selected the gene |
|---|---|---|---|
| KRT17 (Keratin 17) | Upregulated | LUSC | DGE, Lasso, PCA, XGBoost |
| KRT14 (Keratin 14) | Upregulated | LUSC | DGE, PCA, XGboost |
| KRT6A (Keratin 6A) | Upregulated | LUSC | DGE, PCA, XGboost |
| KRT5 (Keratin 5) | Upregulated | LUSC | DGE, PCA, XGboost |
| S100A2 (Calcium Binding Protein A2) | Upregulated | LUSC | DGE, PCA, XGboost |
| TUBA1C (Tubulin Alpha 1c) | Upregulated | LUSC | DGE, Lasso, XGboost |
| CELSR2 (Cadherin EGF LAG seven-pass G-type receptor 2) | Upregulated | LUSC | DGE, Lasso, XGboost |
| TRIM29 (Tripartite Motif Containing 29) | Upregulated | LUSC | DGE, Lasso, PCA |
| REPS1 (RALBP1 Associated Eps Domain Containing 1) | Upregulated | LUSC | DGE, Lasso, XGboost |
| PERP (P53 Apoptosis Effector Related To PMP22) | Upregulated | LUSC | DGE, Lasso, PCA |
| NECTIN1 (Nectin Cell Adhesion) Molecule 1 | Upregulated | LUSC | DGE, Lasso XGboost |
| GPC1 (Glypican 1) | Upregulated | LUSC | DGE, PCA, XGBoost |
| MUC1 (Mucin 1, cell surface associated) | Downregulated | LUAD | DGE, Lasso, PCA |
| ELFN2 (Extracellular Leucine Rich Repeat And Fibronectin Type III Domain Containing 2) | Downregulated | LUAD | DGE, Lasso, XGboost |
| ARHGEF38 (Rho Guanine Nucleotide Exchange Factor 38) | Downregulated | LUAD | DGE, Lasso, XGboost |
| ARHGAP12 ( Rho GTPase Activating Protein 12) | Downregulated | LUAD | DGE, Lasso, XGboost |
| QSOX1 (Quiescin Sulfhydryl Oxidase 1) | Downregulated | LUAD | DGE, Lasso, PCA |