Timeline	Course of events
3 days prior to admission	Typical angina chest pain associated with a dyspnoea Class II of the New York Heart Association
20 h prior to admission	Left hemiplegia and confusion
Day 0	No chest pain on admission, stable haemodynamical status, polypnoea, SaO2 = 93% on room air, left hemi pyramidal syndrome Cerebral computed tomography (CT) scan: mid-cerebral artery ischaemic stroke Electrocardiogram (ECG): sinus rhythm, second-degree Mobitz 1 atrioventricular block, inferior STEMI High troponin levels, inflammatory syndrome Trans-thoracic echocardiogram: inferior and inferolateral wall motion abnormalities, no intracavitary thrombus, normal left ventricular ejection fraction Contrast chest CT scan: no aortic dissection, bilateral pulmonary embolism, bilateral lung condensation, and ground-glass opacities (COVID-19 Reporting and Data System 3) Supra-aortic vessel ultrasound: no plaques or stenosis
Day 1	24 h Holter ECG: sinus rhythm, no rhythm nor conduction abnormalities Result of reverse transcription-polymerase chain reaction (RT-PCR) COVID 19 nasal swab negative, positive SARS-COV2 IgG antibodies, negative IgM antibodies
Day 2	Second RT-PCR COVID-19 swab negative
Day 3	Immunological tests for autoimmune diseases: negative Thrombophilic tests: negative Tumoral markers: negative Antiphospholipid antibodies: negative Doppler of temporal arteries: normal
Day 5	Thoraco-Abdomino-Pelvic CT scan: not remarkable for any tumour, regression of the lung lesions
Day 13	Transoesophageal echocardiography: no patent foramen oval, no left appendage thrombus
Day 14	Coronary angiography: tight stenosis spreads from the proximal right coronary artery (RCA) to the middle RCA Neurological re-assessment → started on optimal doses of enoxaparin
Day 18	Discharge from hospital