Fig. 2.

Inference of demography by MSMC (red lines; ten replicates) and fastsimcoal2 (blue lines; ten replicates) in the presence of BGS generated by strongly deleterious mutations. Directly selected sites comprised 20% of the genome and were masked when performing demographic inference. Exons experience purifying selection specified by (a) DFE6 and (b) DFE5 (see table 1). The true demographic models are given as black lines, with the x-axis origin representing the present day. The dashed lines represent indefinite extensions of the ancestral population sizes. Detailed methods including command lines can be found at: https://github.com/paruljohri/demographic_inference_with_selection/blob/main/CommandLines/Figure2.txt.