Fig. 1.

Destabilizing of HIF-1α through PFC administration. a During of infection with coronavirus, the high expression of angiogenic factors such as VEGF as well as pro-inflammatory cytokines (e.g., interleukin 1 β or IL-1β, IL-6, IL-12, and tumor necrosis factor-α) induce the inflammation as a result of the transcriptional activity of HIF-1α. The increasing levels of pro-inflammatory cytokines as well as previous levels lead to the initiation of cytokine storm which is a serious risk factor for disease severity. b PFC might help the body to tackle the hypoxic condition which results in the formation of cytokine storms through HIF-1α activity. PFC utilization is efficient in HIF-1α instability and reduces HIF-1α expression, which causes reduce the inflammation cascade