Table 3. Risk of Benign Breast Diseases by Family History of Breast Cancer in Mother or Sister.
| Age groupa | HR (95% CI)b | ||||
|---|---|---|---|---|---|
| Epithelial proliferation | Fibroadenoma | Fibrocystic changes | Cyst | ||
| With atypia | Without atypia | ||||
| Premenopausal | 2.11 (1.48-3.00)c | 1.90 (1.46-2.49)c | 1.51 (1.13-2.00)c | 1.39 (1.14-1.69)c | 1.41 (1.09-1.83)c |
| Perimenopausal | 1.43 (0.99-2.06) | 1.68 (1.24-2.28)c | 1.97 (1.44-2.70)c | 1.26 (0.99-1.62) | 1.42 (1.17-1.72)c |
| Postmenopausal | 1.13 (0.58-2.21) | 1.54 (0.80-2.96) | 2.55 (1.20-5.42)c | 1.30 (0.78-2.16) | 1.14 (0.72-1.79) |
Abbreviation: HR, hazard ratio.
a
Premenopausal ages are 25 to 44 years; perimenopausal ages, 45 to 54 years; and postmenopausal ages, 55 to 69 years.
b
Cox proportional hazards regression with time-varying covariates using age as the time scale adjusted for Karolinska Mammography Project for Risk Prediction of Breast Cancer unit, birth cohort, educational level, and number of sisters.
c
Significant association at P < .05.