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. 2021 Jun 20;13(6):2112. doi: 10.3390/nu13062112

Table 2.

Evolution of IBS diagnosis criteria 1.

Diagnosis Criteria Manning Criteria
(1978)
Rome Criteria
(1992)
Rome II Criteria
(1999)
Rome III Criteria
(2006)
Rome IV Criteria
(2016)
Main diagnosis symptoms Abdominal pain that is relieved with a bowel movement Continuous or recurrent symptoms of:
abdominal pain, relieved with defecation, and/or disturbed defecation, usually with bloating or feeling of abdominal distension
At least 12 weeks, which need not be consecutive, in the preceding 12 months of abdominal discomfort or pain * Recurrent abdominal pain or discomfort at least 3 days/month in the last 3 months * Recurrent abdominal pain on average at least 1 day/week in the last 3 months
Pain and/or defecation associated features Looser and more frequent stools
Sensation of incomplete evacuation
Passage of mucus
Abdominal distention
Two or more of:
Altered stool frequency
Altered stool form (hard or loose/watery)
Altered stool passage (straining or urgency, feeling of incomplete evacuation)
Passage of mucus
At least two of three following features:
Relieved with defecation
Change in frequency of stool
Change in form (appearance) of stool
Two or more of the following:
Improvement with defecation
Change in the frequency of stool
Change in the form (appearance) of stool
Two or more of the following:
Related to defecation
Change in the frequency of stool
Change in the form (appearance) of stool

* These criteria should be fulfilled for the last three months with symptom onset at least six months prior to diagnosis; 1 Adapted after: Manning et al., 1978 [195]; Saito et al., 2000 [196]; Sperber et al., 2017 [3]; Lacy et al., 2016 [10]; Lacy and Patel, 2017 [197].