Figure 7.

CT scans showing the patient’s (ID 6) response to treatment with dabrafenib/trametinib (a) Axial CT images of lung demonstrate a secondary lesion (target lesion) in left lower lobe in baseline examination. Patient also has known osseous metastases (nontarget lesions). (b–d) 3, 6, and 9 months after therapy, there is still no evidence of the pulmonary nodule, the osseous metastases remain unchanged, in summary corresponding to partial response. (e,f) 13 months after therapy, there is still no evidence of the pulmonary nodule, but a new mesenteric implant was found, suggestive of progressive disease, which later was confirmed to represent metastatic tissue.