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. 2021 Jun 21;12(6):948. doi: 10.3390/genes12060948

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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AAV-NAC32 reduced dopaminergic degeneration in nigra. (A) Representative photomicrographs of NAC32 and TH immunoreactivity (ir) in the SNcd in a DAT Cre rat receiving AAV-NAC32. NAC32-ir was found in the TH (purple arrows) and non-TH cells (white arrows) near the injection sites. (A1: TH, A2: NAC32, A3: DAPI, and A4: merged, A1–A3). (B) Animals receiving AAV-mCherry (B1, low magnification; B2, high magnification) had less TH immunoreactivity in the SNcd, comparing to (C) those receiving AAV-NAC32 (C1, low magnification; C2, high magnification). (D) TH immunoreactivity was averaged in the SNcd (dotted area in B1) of brain sections between −4.80 to −5.04 mm to the bregma. AAV-NAC32 significantly increased TH-ir in SNcd (* p < 0.001, t-test).