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. 2021 Jun 21;12(6):948. doi: 10.3390/genes12060948

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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AAV-NAC32 reduced the expression of V5-αSyn in nigra. Representative photomicrographs of V5-αSyn-ir in the SNcd of animals receiving AAV-mCherry (A1, low magnification; B1, high magnification) or AAV-NAC32 (A2, low magnification; B2, high magnification). The expression of V5-αSyn in the SNcd (arrows, A1 vs. A2; B1 vs. B2) was reduced bilaterally after AAV-NAC32 injection. (C) V5-αSyn-ir was averaged in the SNcd (as seen in the dotted area in Figure 7B1). AAV-NAC32 significantly reduced V5-αSyn-ir in SNcd (* p = 0.018, t-test).