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. 2021 Jun 18;10(6):741. doi: 10.3390/antibiotics10060741

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The volume and histopathological section of periapical lesions treated by DMADDM. (a) Change of apical shadow volume after treatment with DMADDM. “E” represents E. faecalis, “M” represents multi-bacteria, “D” represents DMADDM; (b) histopathological images after treatment with DMADDM. Chronic inflammatory reaction (INF) in the apical periodontal space, neovascularization (NV) around areas of apical resorption, and neoformed cementum (NC) partially repaired areas of apical resorption. The apical shadow volume was tested through CBCT and calculated by MIMICS V21.0. Each value is mean ± SD (n = 6) (* p < 0.05, ** p < 0.01, *** p < 0.001).