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. 2021 Jun 16;13(6):892. doi: 10.3390/pharmaceutics13060892

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Screening application of the miniaturized and automated human BBB in vitro model. (A) Values (mean ± SD) of the unbound fraction ratio of the CSF/plasma in humans (in vivo Kp,uu,CSF) data obtained from Friden M et al. 2009. Unbound fraction ratios of the brain/plasma predicted in vitro (in vitro Kp,uu,brain) through the 96 TW miniaturized and automated human models. The concentrations were detected by mass spectrometry (LC–MS/MS system) with the calculation of the total amount of unbound molecules recovered (recovery, expressed in percentage). (B) Correlation between the Kp,uu,CSF and Kp,uu,brain nonlinear equations; R² = 0.8808; n = 3; N = 1.