Figure 4.

S1 and N IgG decrease several days before death in non-survivors

(A and B) The trends of median signal intensities of IgG at different time points for S1 (A) and N (B), among three sample groups, i.e., non-severe, severe (survivors), and severe (non-survivors). Samples were grouped per day, and the time points with a sample number less than four were excluded due to lack of statistical significance.

(C and D) Relative S1 IgG signal levels were calculated for each patient by dividing the signal intensity of the samples collected at other time points versus samples collected at 0–2 days before the death of non-survivors (C, n = 35) or the discharge of survivors (D, n = 108). The samples were grouped per 3 days. For each patient, the signals were averaged when there was more than one sample during each 3-day period. The p values were calculated by a two-sided t test between the indicated group and the first group (0–2 days). ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001; n.s., not significant.