Table 1.

Overview of GPCRs that regulate or bind SFKs. Summarized are most of the GPCRs known to activate SFKs in a G protein- or arrestin-dependent manner. Some studies showed a direct interaction between the receptors and the SFKs, while in other studies, activation of the SFK was observed, but a mechanism was not defined.

GPCR	G-Protein	Arrestin	Direct	Other	References
α2AR		Arrestin-2/3			[42]
β2AR		Arrestin-2			[43,44]
β3AR			3rd ICL		[44]
D1R		Arresin-3		unknown	[45,46]
D2R		Arrestin-2		unknown	[47,48]
D4R			3rd ICL		[49]
V1bR				unknown	[50]
V2R			Indication of direct		[50]
GnRH-a	Indication of Gβγ protein				[51,52]
M1R	Indication of Gαq protein				[53]
M2R		Arrestin-2			[43,54]
M3R		Arrestin			[55]
M4R				unknown	[54]
B1R	Gαi			unknown	[56,57]
ETAR				unknown	[58]
ATR2				unknown	[59,60]
Latrophilin-2				unknown	[61]
GPR56 (ADGRG1)				unknown	[62]