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. 2021 Jun 19;10(6):771. doi: 10.3390/pathogens10060771

Figure 2.

Figure 2

The Products of Alphaviral RNA Replication. Translation of the viral genome produces the nonstructural polyprotein P1234. nsP4 is first cleaved off and associated with P123 in order to form the complex that is responsible for synthesizing the minus-strand RNA template. P123 is then further processed into the individual nonstructural proteins nsP1, nsP2, and nsP3. The four fully processed nonstructural proteins then form the replication complex responsible for synthesizing the genomic and subgenomic RNA.