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. 2021 Jun 17;13(6):896. doi: 10.3390/pharmaceutics13060896

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Mean maximal area of the bleb, (b) height, (c) central vascularity and (d) peripheral vascularity (non-bleb) in each treatment group, compared to that of the total area visible of the conjunctiva. Groups: sham-operated animals (control •), collagen matrix (Olo group—x), bevacizumab-loaded collagen matrix (Olo-BVZ group—◊) and bevacizumab-loaded collagen matrix combined with sodium hyaluronate (Olo-BVZ-H5 group—▲). Maximal area of the bleb score: 1 = 0%, 2 = 25%, 3 = 50%, 4 = 75% and 5 = 100%. Height of the bleb in each treatment group applied to the highest point of the bleb: Score from 1 (low) to 4 (high). Vascularity of the central area of the bleb and peripheral vascularity evaluated according to the following score: 1—avascular bleb, 2—normal vascularization, 3—mild vessel inflammation, 4—moderate vessel inflammation; 5—severe vessel inflammation.

(a) Mean maximal area of the bleb, (b) height, (c) central vascularity and (d) peripheral vascularity (non-bleb) in each treatment group, compared to that of the total area visible of the conjunctiva. Groups: sham-operated animals (control •), collagen matrix (Olo group—x), bevacizumab-loaded collagen matrix (Olo-BVZ group—◊) and bevacizumab-loaded collagen matrix combined with sodium hyaluronate (Olo-BVZ-H5 group—▲). Maximal area of the bleb score: 1 = 0%, 2 = 25%, 3 = 50%, 4 = 75% and 5 = 100%. Height of the bleb in each treatment group applied to the highest point of the bleb: Score from 1 (low) to 4 (high). Vascularity of the central area of the bleb and peripheral vascularity evaluated according to the following score: 1—avascular bleb, 2—normal vascularization, 3—mild vessel inflammation, 4—moderate vessel inflammation; 5—severe vessel inflammation.