Table 2.
Univariate CALIPER variables stratified by diagnosis at two tertiary medical centers (labeled derivation and validation).
| Variable | CTD-ILD Derivation (n = 40) | IPF Derivation (n = 85) |
p-Value Derivation |
CTD-ILD Validation (n = 62) | IPF Validation (n = 109) |
p-Value Validation |
|---|---|---|---|---|---|---|
| Total honeycombing, median (±IQR) | 0.5 (1.3) | 2.4 (8.1) | <0.001 | 3.6 (14.3) | 7.4 (17.8) | 0.087 |
| Total reticulation, median (±IQR) | 163.7 (185.8) | 193.6 (153.5) | 0.032 | 116.9 (106.5) | 169.3 (106.5) | 0.003 |
| Total ground-glass opacity, median (±IQR) | 769.5 (649.7) | 790.8 (724.9) | 0.501 | 381.0 (550.7) | 614.2 (660.9) | <0.001 |
| Total VRS, median (±IQR) | 114.6 (59.8) | 174.7 (84.9) | <0.001 | 142.7 (86.5) | 211.3 (78.4) | <0.001 |
| Total normal, median (±IQR) | 1527.9 (975.5) | 1487.8 (923.2) | 0.882 | 1411.8 (814.2) | 1764.6 (940.6) | 0.005 |
IQR: interquartile range, VRS: vessel-related structures; SD: standard deviation. Significant p-values in bold.