Table 3.

Multivariable logistic regression analysis of CALIPER variables relative to diagnosis across two tertiary medical centers (labeled derivation and validation) for a diagnosis of IPF.

Variable	OR Derivation	95% CI Derivation	p-Value Derivation	OR Validation	95% CI Validation	p-Value Validation
Total honeycombing	0.995	0.972–1.019	0.687	1.000	0.996–1.004	0.954
Total reticulation	1.002	0.998–1.005	0.327	1.003	0.999–1.006	0.185
Total ground-glass opacity	0.999	0.997–1.000	0.018	1.000	0.999–1.002	0.379
Total VRS	1.026	1.014–1.037	<0.001	1.008	1.000–1.017	0.047
Total normal	1.000	0.999–1.000	0.365	1.001	1.000–1.001	0.009
Constant	1.000	0.999–1.000	0.365	0.048	0.011–0.208	<0.001

OR: odds ratio; CI, confidence interval; VRS: vessel-related structures. Significant p-values in bold.