Table 2.
Main analysis on current smokers.
| All n = 104 |
Control Group n = 54 |
Eosinophil-Guided Group n = 50 |
p-Value | |
|---|---|---|---|---|
| DAOH14, mean (95% CI) | 9.2 (4.1) | 9.8 (8.7–10.8) | 8.7 (7.5–9.9) | 0.34 |
| Exacerbation or death within 6 months, n (%) | 61 (59) | 30 (60) | 31 (57) | |
| HR (95% CI) | Reference | 0.99 (0.60–1.64) | 0.98 | |
| ICU or death within 6 months, n (%) | 38 (37) | 18 (36) | 20 (37) | |
| OR (95% CI) | Reference | 1.05 (0.47–2.33) | 0.91 | |
| FEV1 pct | ||||
| Baseline, mean (SD) | 33.3 (13,1) | 31.7 (12.3) | 34.7 (13.7) | |
| Day 90, mean (SD) | 42.2(15.7) | 40.0 (15.6) | 44.3 (15.7) | |
| Difference, mean (SD) | 9.1 (11.3) | 8.0 (9.3) | 10.1 (13.0) | 0.46 |
| CAT score | ||||
| Baseline, mean (SD) | 22.3 (7.6) | 22.2 (7.3) | 22.5 (7.9) | |
| Day 90, mean (SD) | 18.0 (7.8) | 19.2 (7.0) | 16.8 (8.4) | |
| Difference, mean (SD) | −4.0 (8.0) | −3.4 (9.4) | −4.5 (6.4) | 0.56 |
Abbreviations: DAOH14, days alive and out of hospital within 14 days; CI, confidence interval; CAT, COPD Assessment Test; FEV1, forced expiratory volume in 1 s; HR, hazard ratio; OR, odds ratio; ICU, intensive care unit; SD, standard deviation.