Skip to main content
. 2021 Jun 17;10(6):736. doi: 10.3390/antibiotics10060736

Table 6.

The PTA for the different gentamicin regimens in critically ill patients according to kidney function (creatinine clearance) at steady state with targets of Cmax/MIC > 8 (for efficacy) and AUC0–24 > 700.

Dosage Regimens PTA (%) CFR (%)
GEN MIC (µg/mL) AUC0–24 > 700 GEN
(mono)		 GEN
(with TGC)
LD MD 0.0625 0.125 0.25 0.5 1 2 4 8 16
Creatinine clearance 0–9 mL/min
3 mg/kg 2.5 mg/kg q 48 h 100 100 100 100 99 42 0 0 0 42.7 76.2 100
5 mg/kg 2.5 mg/kg q 48 h 100 100 100 100 99 41 0 0 0 43.3 76.0 100
7 mg/kg 2.5 mg/kg q 48 h 100 100 100 100 99 42 0 0 0 43.8 76.2 100
Creatinine clearance 10–25 mL/min
5 mg/kg 4 mg/kg q 48 h 100 100 100 100 91 8 0 0 0 6.4 70.7 100
7 mg/kg 3 mg/kg q 48 h 100 100 100 100 78 3 0 0 0 2.4 69.8 100
7 mg/kg 5 mg/kg q 48 h 100 100 100 100 97 17 0 0 0 13.0 72.0 100
8 mg/kg 3 mg/kg q 48 h 100 100 100 100 78 3 0 0 0 2.3 69.8 100
8 mg/kg 5 mg/kg q 48 h 100 100 100 100 96 17 0 0 0 13.2 72.2 100
Creatinine clearance 26–50 mL/min
5 mg/kg 3 mg/kg q 24 h 100 100 100 100 78 3 0 0 0 1.9 69.8 100
5 mg/kg 4 mg/kg q 24 h 100 100 100 100 92 8 0 0 0 6.0 70.6 100
7 mg/kg 3 mg/kg q 24 h 100 100 100 100 79 3 0 0 0 2.3 69.8 100
7 mg/kg 4 mg/kg q 24 h 100 100 100 100 91 8 0 0 0 6.5 70.7 100
8 mg/kg 3 mg/kg q 24 h 100 100 100 100 79 3 0 0 0 2.3 69.8 100
8 mg/kg 4 mg/kg q 24 h 100 100 100 100 92 9 0 0 0 6.6 70.8 100
Creatinine clearance 51–90 mL/min
7 mg/kg 5 mg/kg q 24 h 100 100 100 100 92 6 0 0 0 3.1 70.4 100
7 mg/kg 6 mg/kg q 24 h 100 100 100 100 96 12 0 0 0 5.8 71.3 100
8 mg/kg 5 mg/kg q 24 h 100 100 100 100 92 6 0 0 0 3.6 70.4 100
8 mg/kg 6 mg/kg q 24 h 100 100 100 100 96 12 0 0 0 6.4 71.3 100
8 mg/kg 7 mg/kg q 24 h 100 100 100 100 98 19 0 0 0 10.6 72.6 100
Creatinine clearance 91–130 mL/min
7 mg/kg 5 mg/kg q 24 h 100 100 100 100 89 5 0 0 0 3.2 70 100
7 mg/kg 6 mg/kg q 24 h 100 100 100 100 94 11 0 0 0 6.8 71 100
8 mg/kg 5 mg/kg q 24 h 100 100 100 100 88 6 0 0 0 3.4 70 100
8 mg/kg 6 mg/kg q 24 h 100 100 100 100 94 11 0 0 0 6.2 71 100
8 mg/kg 7 mg/kg q 24 h 100 100 100 100 97 18 0 0 0 9.7 72 100

Abbreviations: AUC, area under the curve; MIC, minimum inhibitory concentration; LD, loading dose; MD, maintenance dose; TGC, tigecycline; GEN, gentamicin.