Table 2.

Characteristics of some relevant clinical studies concerning triglycerides and cerebral amyloidosis.

Study, Year	Participants	Outcome	Results	Conclusions
Choi H.J. et al. [42], 2016	59 cognitively normal elderly individuals	The association between serum lipid measures and cerebral amyloid-beta (Aβ) deposition in cognitively normal elderly individuals.	Higher serum TG level was associated with heavier global cerebral Aβ deposition	Serum TG are closely associated with cerebral amyloidosis.
Nägga K. et al. [44], 2018	318 cognitively normal individuals	The effect of midlife lipid levels on Alzheimer brain pathology 20 years later in cognitively normal elderly individuals.	Higher levels of TG in midlife were independently associated with abnormal CSF Aβ42 and abnormal Aβ42/p-tau ratio. TG were also associated with abnormal Aβ PET in multivariable regression models.	Increased levels of triglycerides at midlife predict brain Aβ and tau pathology 20 years later in cognitively healthy individuals.
Peloso G.M. et al. [46], 2018	157 cases and 2882 controls, individuals 40–60 years old in the Framingham Heart Study	The interaction of a genetic risk score (GRS) of AD risk alleles with mid-life plasma lipid levels (LDL-C, HDL-C, and TG) on risk for AD.	There was a significant interaction between a GRS of AD loci and log TG levels on risk of clinical AD (p = 0.006).	Hypertriglyceridemia during midlife confers a higher risk of AD.

CSF, corticospinal fluid; Chol, total cholesterol; LDL-C, low-density lipoprotein cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; AD, Alzheimer disease.