Table 5.

Key points with exemplar quotes related to general feasibility and specific feasibility related to automated screening approaches and family communication methods.

Domain	Summary of Key Points	Exemplar Quotes
General	Feasibility because of similarity to other initiatives To be successful, clinical staff training and education must occur	“When I’ve had an unusual breast exam and colon... I got a letter, a phone call, and a letter. But they weren’t from my doctor. They were from where I went, clinic or whatever, to get the exam. And they said something very professional, ‘Your, uh, reading was abnormal. We’d like for you to schedule an appointment to come back in.’” (Individual with FH, FG1) “…we’re already doing [automated approaches] as [another participant] said with…with colon cancer.” (Clinician, FG4) “This sounds like an opportunity to educate the physicians … So, I guess this is an opportunity you can teach us and I guess help us reach other people that may not have access to or may not be involved with a physician.” (Clinician, FG5)
Automated approaches	Notification in a variety of ways (mail, e-mail, telephone) Need for dedicated staff/team to manage notification and coordination of automated screening approach results	“So, I say do it all. Send it by mail. Give them a call. Send an email because it’s just, each person receives it differently.” (Individual with FH, FG2) “We really should be approaching this from a team-based approach instead of trying to funnel every piece of information and every decision through the primary care physician. I mean, if you want to do that, you can go hang your shingle up down the street. But the whole idea of having a team-based approach is that we are improving the quality of care. At the same time, we’re letting our providers get home in time to have dinner with their family.” (Clinician, FG4)
Family communication methods	Chatbot is feasible to use, especially if integrated into their patient portal Direct contact is feasible to do but would require permission from the patient and information on their relatives Various types of clinicians could partner with patients in communicating with their relatives	“Linking [the chatbot] to your [patient portal] I think would be…because that’s how I communicate with my doctors is through [the patient portal], so having that information in there I think would be beneficial.” (Individual with FH, FG2) “So, with the permission of the family member or the patient, to speak to others I mean, I don’t have any hesitation trying to, you know, convince them to go and get tested. So, um, if it was, you know, like the index patient, my patient had hesitation about giving me information or sharing anything with anyone else, that might be a different story.” (Clinician, FG5)