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. 2021 Jun 18;22(12):6553. doi: 10.3390/ijms22126553

Figure 7.

Figure 7

Treatment with RD2D3 significantly improved the phenotype of Tg-SwDI mice compared to placebo and cRD2D3 treated mice. An open field test was conducted to analyze and compare the exploratory and anxiety related behavior of RD2D3 and cRD2D3 treated Tg-SwDI mice compared to placebo treated mice (a–d). Mice were allowed to freely explore a square shaped arena for 30 min (imaginarily divided into center and border zone (a)). While there was no difference in the exploratory behavior or in the traveled distance or velocity, there was a significant habituation effect of RD2D3 treated mice to the arena (d). This effect was completely absent in cRD2D3 treated mice (d). Additionally, a Morris water maze (MWM) was performed in which mice were trained for 5 days to find a hidden platform (e). Both treatment groups (RD2D3 and cRD2D3) found the hidden platform faster than placebo treated mice and spent more time in the platform zone during the probe trial (f). Data are shown as mean ± SEM (placebo N = 13, RD2D3 N = 14 and cRD2D3 N = 12). ** p < 0.01 and * p < 0.05.