Table 1.

Summary of the role of asparagine in solid tumor studies.

References	Biological Processes	Functions
Zhang J, [71]	Glutamine starvation	Suppresses ER stress and apoptosis
Pavlova NN, [25]	Glutamine starvation	Supports GLUL expression and glutamine biosynthesis
Gwinn DM, [75]	KRAS-driven lung cancer	NRF2-dependent de novo biosynthesis to support tumor cell growth
LeBoeuf SE, [76]	KRAS-driven lung cancer	Demand for uptake to mitigate NRF2-dependent glutamate export
Linares JF, [77]	Prostate cancer	Secreted by CAFs to support tumor cell growth
Knott SRV, [78]	Breast cancer metastasis	Supports lung metastasis via EMT gene expression
Halbrook CJ, [79]	Pancreatic cancer	Protect tumor cells from ETC inhibition
Hinze L, [80]	Colorectal cancer	GSK3-dependent proteolytic scavenging to protect from L-asparaginase treatment