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Methylation levels of CRF receptor genes estimated by qMSP in ccfDNA from adjuvant and metastatic CRC patients and healthy individuals (control). (A) Median methylation levels of CRFR1 and CRFR2. Boxplots depict methylation levels in relation to study groups for (B) CRFR1 and (C) CRFR2; * p: adjuvant vs. metastatic; # p: adjuvant vs. control; ccfDNA: circulating cell-free DNA; qMSP: quantitative methylation-specific PCR; CRC: colorectal cancer.
