Table 3.

DMCs at the first exon or close to the TSS identified by in silico analysis in CRFR1.

STUDY	CpG ID	Compared Study Groups	Mean β-Value 1 *	Mean β-Value 2 *	Δ β-Value #	Methylation, CRC vs. Normal	Gene Location	Location Relative to CpG	FDR
GSE149 282	cg08473090	Adjacent vs. CRC tissue	0.089	0.330	+0.241	Up	TSS1500	Island	3.174 × 10−3
GSE149 282	cg08929103	Adjacent vs. CRC tissue	0.563	0.239	−0.323	Down	TSS1500	N shore	4.453 × 10−5
GSE149 282	cg11338426	Adjacent vs. CRC tissue	0.103	0.269	+0.166	Up	First Exon	Island	1.786 × 10−2
GSE149 282	cg12577105	Adjacent vs. CRC tissue	0.047	0.163	+0.116	Up	TSS1500	Island	8.456 × 10−3
GSE149 282	cg13521908	Adjacent vs. CRC tissue	0.077	0.249	+0.172	Up	First Exon	Island	3.136 × 10−3
GSE149 282	cg18757974	Adjacent vs. CRC tissue	0.062	0.218	+0.156	Up	TSS1500	Island	7.654 × 10−3
GSE122 2126	cg08929103	Healthy vs. CRC ccfDNA	0.767	0.477	−0.291	Down	TSS1500	N shore	1.261 × 10−3
GSE122 2126	cg13521908	Healthy vs. CRC ccfDNA	0.117	0.213	+0.096	Up	First Exon	Island	2.545 × 10−2

* Mean β-value 1 represents methylation in normal tissues and mean β-value 2—methylation in diseased tissues; ^# Δ β-value: mean β-value 2 − mean β-value 1; DMC: differentially methylated CpG; FDR: false discovery rate; ccfDNA: circulating cell-free DNA.