Table 4.
Multivariate Cox proportional hazards models for overall survival of pancreatic ductal adenocarcinoma patients.
| Variable | Multivariate Analysis: IRS | Multivariate Analysis: IS | Multivariate Analysis: PS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | ||||
| Lower | Upper | Lower | Upper | Lower | Upper | |||||||
| KIF11 IRS (low vs. high) | 0.06 | 0.005 | 0.64 | 0.02 | - | - | - | - | - | - | - | - |
| KIF11 IS (low vs. high) | - | - | - | - | 3.05 | 1.29 | 7.19 | 0.01 | - | - | - | - |
| KIF11 PS (low vs. high) | - | - | - | - | - | - | - | - | 0.31 | 0.06 | 1.53 | 0.15 |
| KIF14 IRS (low vs. high) | 0.20 | 0.08 | 0.51 | 0.001 | - | - | - | - | - | - | - | - |
| KIF14 IS (low vs. high) | - | - | - | - | 0.25 | 0.10 | 0.67 | 0.006 | - | - | - | - |
| KIF14 PS (low vs. high) | - | - | - | - | - | - | - | - | 0.45 | 0.17 | 1.21 | 0.11 |
| Age (≤ 60 vs. ≥ 60) | 1.15 | 0.50 | 2.64 | 0.74 | 1.61 | 0.69 | 3.73 | 0.27 | 1.71 | 0.68 | 4.25 | 0.25 |
| Gender (female vs. male) | 0.93 | 0.37 | 2.30 | 0.87 | 0.80 | 0.32 | 1.98 | 0.63 | 0.87 | 0.33 | 2.29 | 0.78 |
| Grade (G1 vs. G2-G3) | 3.00 | 0.24 | 37.98 | 0.40 | 6.00 | 0.47 | 76.79 | 0.17 | 4.64 | 0.44 | 48.57 | 0.20 |
| pN (absent vs. present) | 1.05 | 0.38 | 2.90 | 0.93 | 1.76 | 0.55 | 5.69 | 0.34 | 1.20 | 0.38 | 3.73 | 0.76 |
| pT (T1-T2 vs. T3-T4) | 2.17 | 0.66 | 7.14 | 0.20 | 2.06 | 0.68 | 6.21 | 0.20 | 1.91 | 0.63 | 5.73 | 0.25 |
| Stage (I-II vs. III-IV) | 2.06 | 0.73 | 5.77 | 0.17 | 1.43 | 0.48 | 4.24 | 0.52 | 1.91 | 0.68 | 5.31 | 0.22 |
| PNI (absent vs. present) | 0.74 | 0.29 | 1.91 | 0.54 | 1.27 | 0.48 | 3.36 | 0.64 | 0.74 | 0.27 | 2.03 | 0.56 |
| VI (absent vs. present) | 3.43 | 1.30 | 9.06 | 0.01 | 4.09 | 1.49 | 11.20 | 0.006 | 1.96 | 0.70 | 5.51 | 0.20 |
Abbreviations: HR, hazard ratio; CI, confidence interval; IS—immunointensity; PS—immunopercentage; IRS—immunoreactive score; VI—vascular invasion; PNI—perineural invasion. HR: adjusting for age, gender, histological grade, tumor stage, pT, pN, and study. “-“ indicates that the variable was not included in multivariate analysis. Bold values denote statistically significant p-values (p < 0.05).