Table 6.
Variable | Univariate Analysis | Multivariate Analysis: KIF11 | Multivariate Analysis: KIF14 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | ||||
Lower | Upper | Lower | Upper | Lower | Upper | |||||||
KIF11 (low vs. high) | 2.25 | 1.47 | 3.45 | 0.0002 | 1.75 | 1.13 | 2.70 | 0.01 | - | - | - | - |
KIF14 (low vs. high) | 2.99 | 1.97 | 4.54 | <0.0001 | - | - | - | - | 2.65 | 1.70 | 4.15 | <0.0001 |
Age (≤ 60 vs. ≥ 60) | 1.41 | 0.90 | 2.21 | 0.13 | 1.24 | 0.77 | 1.98 | 0.38 | 1.28 | 0.80 | 2.04 | 0.31 |
Gender (female vs. male) | 0.81 | 0.54 | 1.23 | 0.33 | 0.78 | 0.51 | 1.20 | 0.26 | 0.84 | 0.54 | 1.30 | 0.41 |
Grade (G1 vs. G2-G3) | 2.18 | 1.15 | 4.13 | 0.02 | 1.53 | 0.80 | 2.95 | 0.20 | 1.21 | 0.61 | 2.39 | 0.59 |
pN (absent vs. present) | 2.10 | 1.25 | 3.52 | 0.005 | 2.00 | 1.15 | 3.47 | 0.01 | 2.09 | 1.19 | 3.67 | 0.01 |
pT (T1-T2 vs. T3-T4) | 2.21 | 1.14 | 4.28 | 0.02 | 1.34 | 0.65 | 2.75 | 0.43 | 1.29 | 0.63 | 2.65 | 0.49 |
Stage (I-II vs. III-IV) | 0.74 | 0.23 | 2.34 | 0.60 | - | - | - | - | - | - | - | - |
Significant p-values (p < 0.05) are marked in bold. Abbreviations: CI, confidence interval; HR, hazard ratio; TCGA, the Cancer Genome Atlas. HR: adjusting for age, gender, histological grade, pN, pT, and each marker separately. Owing to the strong correlations between KIF11 and KIF14 mRNA levels, they were not included in the same multivariate model. “-“ indicates variable was not included in multivariate Cox analysis.