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. 2021 Jun 16;13(12):3017. doi: 10.3390/cancers13123017

Table 6.

Univariate and multivariate Cox proportional hazards models for overall survival of TCGA patients with pancreatic adenocarcinoma.

Variable Univariate Analysis Multivariate Analysis: KIF11 Multivariate Analysis:
KIF14
HR 95% CI p HR 95% CI p HR 95% CI p
Lower Upper Lower Upper Lower Upper
KIF11 (low vs. high) 2.25 1.47 3.45 0.0002 1.75 1.13 2.70 0.01 - - - -
KIF14 (low vs. high) 2.99 1.97 4.54 <0.0001 - - - - 2.65 1.70 4.15 <0.0001
Age (≤ 60 vs. ≥ 60) 1.41 0.90 2.21 0.13 1.24 0.77 1.98 0.38 1.28 0.80 2.04 0.31
Gender (female vs. male) 0.81 0.54 1.23 0.33 0.78 0.51 1.20 0.26 0.84 0.54 1.30 0.41
Grade (G1 vs. G2-G3) 2.18 1.15 4.13 0.02 1.53 0.80 2.95 0.20 1.21 0.61 2.39 0.59
pN (absent vs. present) 2.10 1.25 3.52 0.005 2.00 1.15 3.47 0.01 2.09 1.19 3.67 0.01
pT (T1-T2 vs. T3-T4) 2.21 1.14 4.28 0.02 1.34 0.65 2.75 0.43 1.29 0.63 2.65 0.49
Stage (I-II vs. III-IV) 0.74 0.23 2.34 0.60 - - - - - - - -

Significant p-values (p < 0.05) are marked in bold. Abbreviations: CI, confidence interval; HR, hazard ratio; TCGA, the Cancer Genome Atlas. HR: adjusting for age, gender, histological grade, pN, pT, and each marker separately. Owing to the strong correlations between KIF11 and KIF14 mRNA levels, they were not included in the same multivariate model. “-“ indicates variable was not included in multivariate Cox analysis.