Table 2.

Dosage regimens of individual trials using Botox®.

First Author, Year	Total Dose	Gastrocnemius		Soleus	TP	FDL	FDB	FHL	EHL	Reconstituted
		Medial	Lateral
Mancini.2005 *	167 U	50 U		50 U	50 U	50 U	50 U			100 u/2 mL
	322 U	100 U		75 U	100 U	75 U	75 U
	540 U	200 U		100 U	200 U	100 U	100 U
Kaji.2010	300 U	75 U	75 U	75 U	75 U					100 U/5 mL
Dunne.2012	200 U	50 U		80 U	70 U					20 U/mL
	300 U	75 U		125 U	100 U
Pimentel.2014	100 U	50 U	50 U							100 U/2 mL
	300 U	100 U	100 U	100 U
Fietzek.2014	230 U	60 U	30 U	70 U	70 U					100 U/2 mL
Tao.2015	200 U	50 U	50 U	50 U	50 U					NA
Wein.2018	300–400 U	75 U	75 U	75 U	75 U	≤100 U * into optional muscles				100 U/4 mL
Kerzoncuf.2019 *	227 U	50–100 U		50–160 U	50–100 U	50–100 U		25–50 U	25 U	NA

Abbreviations: U: unit, TP: tibialis posterior, FDL: flexor digitorum longus, FDB: flexor digitorum brevis, FHL: flexor hallucis longus, EHL: extensor hallucis longus. NA: Not available. *: individualized for each patient.