Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 17;11(6):901. doi: 10.3390/biom11060901

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Proposed neutrophil extracellular trap (NET) targeting strategies. Peptidyl arginine deiminase 4 (PAD4) inhibitors block PAD4-mediated citrullination of histones, thereby preventing heterochromatin decondensation and subsequent NET release. Recombinant thrombomodulin (rTM) can inhibit high mobility group box 1 protein (HMGB1), reducing capture and migration of tumor cells by NETs. DNAse I and chloroquine (CQ) degrade and decrease secretion of decondensed DNA, respectively, thereby reducing interactions of decondensed DNA with the receptor for advanced glycation end products (RAGE), preventing pancreatic stellate cell (PSC) activation and subsequent extracellular matrix (ECM) deposition. ROS, reactive oxygen species; MMPs, matrix metalloproteinases.