Figure 2.

Summary of the ovarian and reproductive features of Omcg1^ocKo females. Oocyte death and arrest of folliculogenesis at the primary follicle stage, leading to a kind of premature ovarian insufficiency (POI), were observed in Omcg1^ocKo females. The ovarian somatic compartment was remodeled, allowing the production of oestradiol (E2), which might occur along a two-cell compartment scheme similar to what is found between theca cells and granulosa cells in preovulatory follicles. Surprisingly, despite the absence of cyclic follicular growth and then of preovulatory follicles, Omcg1^ocKo females displayed features of sexual cyclicity as wild-type mice (adapted from [4]).