Figure 6.

Stabilization of thrombi with IL-4-stimulated THP-1 cells occurs in a transglutaminase-dependent manner. Model thrombi were formed with PNP or FXIII^-/- plasma and FITC-labelled fibrinogen under arterial shear rates, and lysis was subsequently induced by tPA (1 μg/mL). Fluorescence release is directly proportional to the degree of fibrinolysis. FXIII^-/- thrombi were formed without (black) and with (pink) 3 × 10⁵/mL IL-4 stimulated THP-1 cells in the absence (closed symbols) and presence (open symbols) of the TG inhibitor. Values represent the mean ± SEM, n = 4, ** p < 0.005 vs. IL-4 stimulated THP-1 cells.