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. 2021 Jun 16;26(12):3677. doi: 10.3390/molecules26123677

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of WAY 100,635 (5-HT1A receptor antagonist) and isamoltane (5-HT1B receptor antagonist) pre-treatment on cardamonin against thermal hyperalgesia of CCI-induced neuropathic pain mice were evaluated using Hargreaves’ Plantar test. Data were presented as mean ± SEM (n = 6). The caret, hash, and asterisks denote the significance levels (one-way ANOVA, followed by Tukey’s post hoc test, ^{^^^^} p < 0.0001 as compared to sham, ^#### p < 0.0001 as compared to vehicle and **** p < 0.0001 as compared to cardamonin-treated group. SHM (Sham); VEH (Vehicle, 10 mL/kg i.p.); C (Cardamonin, 10 mg/kg i.p.); WAY (WAY 100635, 1.0 mg/kg, i.p.); ISA (Isamoltane, 2.5 mg/kg, i.p.).