Skip to main content
. 2021 Jun 20;13(6):1178. doi: 10.3390/v13061178

Figure 1.

Figure 1

Different viruses employ various strategies in order to access to the nucleus. (A) The HBV travels to the vicinity of the NPC protected by its capsid. Thus, it employs importin α and β to access the nucleus (1). The small size of HBV capsid permits the import of this structure complete to the nucleus. The uncoating of HBV capsid takes place assisted by Nup 153 (2) releasing the genome in the nucleus of the cell (3). (B) The HSV capsid is too large to be imported complete to the nucleus. Therefore, the HSV binds to the cytoplasmic filaments of NPC via Nup358 and Nup214 (1). Once the capsid docks at the NPC, the viral DNA is injected to the nucleus (2). (C) The adenovirus uncoating begins during the release of the viral capsid from the endosomes (1) and is completed at the NPC (2), where there is a complex formed by the capsid, Nup 358, Nup214, microtubules, and kinesin. The mechanical stress caused by the binding to microtubules and to the NPC contributes to completing the tear down of adenovirus capsids. Eventually, the viral DNA is released in the nucleus (3). Created with BioRender.com, accessed on 7 June 2021.