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. Author manuscript; available in PMC: 2021 Aug 4.
Published in final edited form as: Cell Metab. 2020 Jun 8;32(2):243–258.e6. doi: 10.1016/j.cmet.2020.05.017

Figure 6. Adipose tissue iNKT cells produce IFNγ, which is required for proper metabolic function in lean fat.

Figure 6.

(a) Percentage of IFNγ+ adipose tissue iNKT cells from mice injected with vehicle or αGalCer (left) or vehicle or LPS (right) four hours prior (n = 4–7 mice per group).

(b) Percentage among CD45+ and absolute number of ATMs in WT versus IFNγ KO mice (n = 8–10 mice per group).

(c) Transcript levels Il6, Nos2, and Arg1 in adipose tissue of WT and IFNγ KO mice (n = 3–7 mice per group).

(d-e) Fasting glucose (d) and glucose tolerance test (e) of WT versus IFNγ KO mice (n = 14–15 mice per group).

(f-g) Fasting glucose (f) and glucose tolerance test (g) of WT versus IFNγR KO mice (n = 7–10 mice/group).

NS, not significant (P > 0.05); *P < 0.05; **P < 0.01; ***P < 0.001. Two tailed Student’s t-test. Mann Whitney U test was use to assess significance for Arg1 in Fig. 6c, as the data were not normally distributed. Error bars indicate mean (± S.E.M.). Data representative of (a, b, c, e, f, g, i) or combined from (d, h) two independent experiments.