Figure 5.
Top panel: Time sequence of changes in percentage time per hour of epileptiform discharge (ED) activity after umbilical cord occlusion (UCO) in asphyxia + vehicle (black circles, n = 6; 3 female, 3 male) and asphyxia + GDQ (green squares, n =7; 4 female, 3 male) groups. Data between 0 and 48 h and between 120 and 168 h post-UCO were batch analyzed at 12 h intervals. Data between 60 and 108 h post-UCO are 1 h averages. Data are mean ± SEM. Statistical significance was determined by repeated measures ANOVA followed by Fisher’s LSD post hoc analysis: * p < 0.05, asphyxia + GDQ vs. asphyxia + vehicle. Bottom panel: Relationship between the sum of all minutes of epileptiform discharge (ED burden, hours), measured between 72 and 96 h post-UCO, and the number of surviving neurons (NeuN-positive cells/mm2) in the striatal caudate nucleus after 7 days recovery for the asphyxia groups (asphyxia + vehicle and asphyxia + GDQ, r2 = 0.61, p < 0.05, black solid line). Dashed lines are the 95% confidence intervals. Green squares: asphyxia + GDQ; black circles: asphyxia + vehicle.