Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 21;22(12):6614. doi: 10.3390/ijms22126614

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The molecular mechanisms of MSA cytotoxicity mediated by intracellular glutathione in cancer cells. Reduced glutathione (GSH), present in cancer cells in large amounts, is extremely important for the metabolism of MSA. In the process of converting MSA into methylselenol, glutathione is oxidized (GSSG) and free radicals, in particular, hydrogen peroxide, increase, which are the cause of the oxidative degradation of membrane lipids. In addition, MSA, through the oxidation of GSH, contributes to the G1 arrest of the cell cycle by suppressing the activity of cyclin E1 and activating the cyclin-dependent kinase 2 inhibitor p27Kip1.