Skip to main content
. 2021 Jun 21;13(6):919. doi: 10.3390/pharmaceutics13060919

Table 6.

Summary of PAT-based modeling method applied in tableting process.

Equipment Type Monitored IQAs
in Process		 PAT Tool
(Model)		 Related CQAs of Finished Product Ref
Direct compression
  • -

    Tablet hardness

 NIR spectrometer
(NIR systems Rapid Content Analyzer Model 5000, Silver Spring, MD, USA)
  • -

    Content uniformity

  • -

    Dissolution

 [154]
  • -

    Drug content

 NIR spectrometer
(VisioNIR ls, Uhlmann VisioTec GmbH, Laupheim, Germany)
  • -

    Assay

  • -

    Content uniformity

 [213]
  • -

    Content uniformity

 NIR spectrometer
(FOSS NIRSystems Model 5000, Silver Spring, MD, USA)
  • -

    Content uniformity

 [273]
  • -

    Drug content

 NIR spectrometer
(MPA, Bruker Optics, Ettlingen, Germany)
  • -

    Assay

  • -

    Content uniformity

 [278]
Rotary tablet compression
  • -

    Drug content

 NIR spectrometer
(SentroPAT FO, Sentronic GmbH, Germany)
  • -

    Assay

  • -

    Content uniformity

 [279]
  • -

    Drug content

 NIR spectrometer
(ePAT611, Expo Technology, St Louis, MO, USA)
  • -

    Assay

  • -

    Content uniformity

 [2]
  • -

    Drug content

 NIR spectrometer
(SentroPAT FO, Sentronic GmbH, Germany)
  • -

    Assay

  • -

    Content uniformity

 [136]
  • -

    Drug content

  • -

    Content uniformity

 NIR spectrometer
(MCS 611 NIR 2.2, Carl Zeiss, Germany)
  • -

    Assay

  • -

    Content uniformity

 [280]
  • -

    Content uniformity

 NIR spectrometer
(Foss NIRSystems, Inc., Laurel,
MD, USA)
  • -

    Content uniformity

 [281]