Table 4.
LncRNAs with a role in choriocarcinoma.
| LncRNA | Locus | Role | Molecular Functions | Target Pathway | Sources |
|---|---|---|---|---|---|
| MALAT1 | 11q13.1 | Oncogene | Sponge of miR-218 | Unknown | Three CC cell lines, JEG-3, JAR, and BeWo cells, and a normal cell line human trophoblast cells (HT cells) [60] |
| H19 | 11p15.5 | Oncogene | Unknown | PI3K/AKT/mTOR [61] | Placenta, androgenetic moles, and choriocarcinoma [62]; CC cell line JEG-3, including MTX- and 5-FU-resistant variants [61] |
| MEG3 | 14q32.3 | Tumor suppressor | Unknown | Unknown | Placenta; 4 cell-lines associated with pregnancy, including HTR-8/SVneo, JEG-3, WISH, and HUVEC [63] |
| PCA3 | 9q21-22 | Oncogene | Sponge of miR-106b | Unknown | Three CC cell lines, JAR, BeWo, and JEG-3, and the human chorionic trophoblast cell HTR-8 [64] |
| LINC00261 | 20p11.21 | Tumor suppressor | Unknown | Unknown | Sixty CC tissues and 60 adjacent non-cancerous tissues; 3 CC cell lines, namely, BeWo CCL-98, JEG-3, and JAR [65] |
| OGFRP1 | 22q13.2 | Oncogene | Unknown | AKT/mTOR | Two CC cell lines, JEG-3 and JAR [66] |
| MIR503HG and LINC00629 | Xq26 | Tumor suppressor | Unknown | Unknown | RNA samples from a commercial normal human tissue panel and 18 cancer cell lines, JEG-3 cell line [67] |