Figure 1.

Overview of the RNA m⁶A modification and A-to-I RNA editing and their known writers, readers, and erasers. m⁶A modification and A-to-I editing occur in most RNA species. ADAD1-2, adenosine deaminase domain-containing protein 1-2; ADAR1-3, double-stranded RNA-specific adenosine deaminase 1-3; ADAT1-3, adenosine deaminases acting on tRNAs; ALKBH5, alkB homolog 5 RNA demethylase; A-to-I, adenosine-to-inosine RNA editing; circRNA, circular RNA; ENDOV, human endonuclease V; eIF3, eukaryotic initiation factor 3; EWSR1, Ewing sarcoma breakpoint region 1 protein; FMRP, fragile X retardation protein; FTO, fat mass and obesity associated protein; G3BP1, Ras GTPase-activating protein-binding protein 1; HAKAI, E3 ubiquitin-protein ligase Hakai; HNRNP-A2B1,-C,-G, heterogeneous nuclear ribonucleoprotein A2/B1 and C1/C2 and G; HuR, human antigen R; IGF2BP1-3; The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3; LIN28A, Lin-28 homolog A; lncRNA, long non-coding RNA; METTL3,-14,-16, N6- adenosine-methyltransferase catalytic subunit/non-catalytic subunit/METTL16; METTL5, methyltransferase Like 5; mRNA, messenger RNA; miRNA, microRNA; Prcc2a, proline rich coiled-coil 2 A; RBM15, RNA binding motif protein 15; rRNA, ribosomal RNA; snoRNA, small nucleolar RNA; TRMT112, TRNA methyltransferase subunit 11-2; tRNA, transfer RNA; VIRMA, vir like m⁶A methyltransferase associated; WTAP, Wilm’s tumor associated protein; (YTH)DC1-2, YTH domain-containing protein 1 ja 2; (YTH)DF1-3, YTH N6-methyladenosine RNA binding protein 1-3; ZCCHC4, zinc finger CCHC-type containing 4; ZC3H13, zinc finger CCCH domain-containing protein 13; *, miRNAs can also derive from pre-mRNA introns.