Table 4.
Current controller and collaborator centers of the IHD-EPITRAN study with respective main responsibilities. A-to-I, Adenosine-to-inosine RNA editing; AVR, Aortic valve replacement surgery cohort III; AVS, aortic valve stenosis; CABG, coronary artery bypass surgery cohort II; CCTA, coronary computed tomography angiogram cohort IV; ICA, invasive coronary angiography; meRIP-seq, methylated RNA immunoprecipitation sequencing; m6A, N6-methyladenosine; PCI, percutaneous coronary intervention; TTE, transthoracic echocardiography.
| Controllers | Main responsibility area/task |
| Heart and Lung Center & Cardiac Unit, Helsinki University Hospital (HUS), Finland | Patient recruitment; clinicial evaluations; operations (PCA, CABG, AVR); imagings (ICA, CCTA, TTE); control visits; study sample collection; registry data storage and governace; sample storage |
| Department of Pharmacology, University of Helsinki (UH), Finland | Coordination of (1) collaboration, (2)funding acquisition and (3) competitve tendering; RNA exctraction and initial sample quality measurements; academic analyses; scientific publishing |
| Collaborator centers | |
| Heart Hospital, Tampere Unviersity Hospital (TAYS), Finland | Patients recruitment (cohort III); clinical evaluations; operations (AVR); imagings (ICA, TTE); control visits; sample collection; clinical data and sample storage |
| Helsinki and Tampere Biobanks, Finland | Additional biobank sample collection and storage; DNA extraction; protocal designing |
| Meilahti Clinical Proteomics Core Faculity, UH, Finland | Targeted proteomics from plasma and snap-frozen RAA tissue samples; protocal designing |
| Chemistry Unit, Ginnish Food Authority, Finland | Specific measurements and analyses of modified RNA necleotides from via UHPLC-MS.MS methodolgy |
| Folkhälsan Research Center, Finland | Leading bioinformatics of second and third generation RNA sequencing targeting modifications (m6A) as well as DNA-to-RNA sequence matching (A-to-I) |
| Middle East Technical Univeristy, Ankara, Turkey | Ollaboration in the bioinformatics with Folkhälsan, specific share of responsiblities is decided later |
| Koç University, Istanbul, Turkey | See above |
| University of Tartu, Estonia | Leading the collaboration for the development of potential binding molecules as novel drugs for IHD |