Table 9.
Summary of studies that used NMDA antagonists to treat tinnitus.
| Drug | Authors | Subjects | Success Rate | |
|---|---|---|---|---|
| Acamprosate | Azevedo [66] | 25 | The beneficial effect increased from 1 month to 3 months | |
| Caroverine | Denk [63] | 30 | No improvement | 11/30 |
| 1 point better | 14/30 | |||
| 2 points better | 4/30 | |||
| 3 points better | 1/30 | |||
| Domeisen [64] | 24 | Better | 0/24 | |
| Unchanged | 20/24 | |||
| Worse | 4/24 | |||
| Memantine | Figueiredo [65] | 43 | Worsening (THI 10) | 9/43 |
| Stable (−10 to 10) | 18/43 | |||
| Improvement (THI −10) | 16/43 | |||
| Neramexane | Suckfüll [68] | 317 | Significantly better scores in the 50 mg/d group | |