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. 2021 Jun 16;22(12):6441. doi: 10.3390/ijms22126441

Figure 3.

Figure 3

VIP-modulated inflammatory proteins. Secreted levels of (a,c) CHI3L1 and (b,d) PTX3 were determined by ELISA and Multiplex, respectively, in the secretomes from SF and AC alone and in co-culture (n = 6). Data are presented as mean ± SEM of triplicate determinations. (a,b) Constitutive protein expression of (a) CHI3L1 and (b) PTX3 in the secretomes from SF and AC alone and in co-culture at 48 h. Results are presented as pg corrected by the number of cells for each condition. *** p < 0.001. (c,d) Protein expression of (c) CHI3L1 and (d) PTX3 in the SF-AC co-cultures secretomes at 48 h of treatment with and without 10 nM 45 kDa Fn-fs in the presence and absence of 10 nM VIP. * p < 0.05, ** p < 0.01 Fn-fs+VIP vs. Fn-fs.