Figure 6.

Eritoran decreased liver inflammation in the carbon tetrachloride (CCl₄)-injured mice. (A) Serum ALT levels. (B) Serum LPS levels. (C) Liver weight (LW) and spleen weight (SW). (D) Hematoxylin and eosin (H&E), (E) myeloperoxidase (MPO) staining and (F) immunohistochemical staining for F4/80 of the liver sections and quantification of the MPO-positive stained cells (arrow) as well as the positively stained F4/80 areas (%). Scale bar = 100 μm. Tissue sections from all the mice were stained and quantified (means ± SEM). (G) Hepatic transcript levels of tumor necrosis factor-α (Tnfa) and monocyte chemoattractant protein 1 (Mcp1). Ctrl-V/Ctrl-E: the mice that received corn oil (Ctrl) were injected with a vehicle (Ctrl-V, n = 8) or eritoran (Ctrl-E, n = 8); CCl₄-V/CCl₄-E: the mice that received carbon tetrachloride (CCl₄) were randomized to be injected with a vehicle (CCl₄-V, n = 9) or eritoran (CCl₄-E, n = 9); ^# p < 0.05 vs. Ctrl-V; * p < 0.05 vs. CCl₄-V.