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Schematic representation of the mechanism via which PAG regulates the intestinal barrier. In leaky gut sufferers administered PAG, the MAPK/ERK signaling pathway is activated in the intestinal epithelial cells, leading to Thr70-specific phosphorylation of the translation repressor 4E-BP1, resulting in a translational increase in the tight junction related protein ZO-1, to finally reinforcing the intestinal tight junction.
