Figure 1.

Human and murine islet insulin secretion in conditions of extremely high glucose. Islets from human donors (A) and mice (B) were placed in mannitol balanced KRB solutions containing glucose ranging from 0 mM to 144 mM for 1 h. Insulin secretion from each donor or mouse replicate was normalized to their respective maximal value and averaged. Dotted linear trendlines are drawn for 0–24 mM and 24–84 mM glucose to indicate slope, Spearman’s rho, and the respective p-value.