Table 1.

A summary of oHSV variants and their applications in preclinical models.

oHSV Variant	Genetic Changes	Preclinical Models
rRp450	ICP6 deletion, insertion of CYP2B1.	Glioblasoma [42] Colon carcinoma [43] Sarcoma [44]
rQNestin34.5v.2	Nestin promoter drives the expression of ICP34.5.	Glioma [45]
G207	Diploid deletion of γ34.5, inactivation of UL39.	Glioma [46,47] Cervical cancer [48]
G47Δ	Diploid deletion of γ34.5, inactivation of UL39, deletion of α47.	Meningioma [49] Gastic cancer [50] Liver cancer [51] Breast cancer [52] Thyroid carcinoma [53] Urological cancers [54]
G47Δ-TRAIL	G47Δ expressing TRAIL	Glioblastoma [41]
oHSV-IL12	G207 expressing IL12	Ovarian cancer [55] Breast cancer [56]
oHSV-GM-CSF	G207 expressing GM-CSF	Advanced melanoma [18]