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. 2021 Jun 19;13(12):3065. doi: 10.3390/cancers13123065

Table 1.

FOXM1 isoforms and variants.

Isoform Name Structure Known Function Size RefSeq ID Ensembl ID UniProt ID References
Well-Characterized FOXM1 Isoforms
FOXM1a Includes alternative exons Va and VIIa Not transcriptionally active 801 aa NM_202002 ENST00000342628 Q08050-3 [13,14,28,29]
FOXM1b Omits alternative exons Va and VIIa Transcriptionally active 748 aa NM_202003 ENST00000361953 Q08050-2 [13,14,28,29]
FOXM1c Includes alternative exon Va; omits alternative exon VIIa Transcriptionally active 763 aa NM_021953 ENST00000359843 Q08050-1 [13,14,28,29]
Other Reported FOXM1 Isoforms
FOXM1b1 Omits alternative exons Va and VIIa; omits alanine residue at the beginning of exon III; includes glutamine residue at the end of exon V Transcriptionally active with functions similar to FOXM1b 748 aa NM_001243088 ENST00000627656 A0A0D9SFF0 [33]
FOXM1b2 Omits alternative exons Va and VIIa; omits alanine residue at the beginning of exon III Transcriptionally active with functions similar to FOXM1b 747 aa NM_001243089 N/A N/A [33]
FOXM1d Includes alternative exon VIIa; omits alternative exon Va Not transcriptionally active; binds directly to oncogenic proteins 786 aa N/A N/A A0A2P9DTZ0-1 [31,34,35]
FOXM1 variant gAug10 No evidence at the protein level N/A N/A N/A ENST00000536066 N/A [36]
FOXM1 variant lAug10 No evidence at the protein level N/A N/A N/A N/A N/A [36]