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Diagrammatic illustration of six isoforms of HLA class I molecules. The upper row shows the structures of intact, trimeric, closed conformers (CCs) of HLA. Note the shortened cytoplasmic tail. The lower row shows monomeric HLA-I (open conforms OCs). OCs of HLA-I expose epitopes masked by β2m. These epitopes, particularly 117AYDGKDY123 and 126LNEDLRSWTA135, are found in almost all alleles of the six isoforms of HLA.
