Figure 1.

Schematic illustration of the regulation of function of transcriptional factors (TF) by FLNA. Membrane-bound FLNA mediates extracellular signals to the cytoskeleton. FLNA interacts with multiple TF in a cell-specific manner in the cytoplasm. Increased calpain protease activity cleaves membrane-bound FLNA releasing the FLNA^CT, which is translocated to the nucleus together with TF. As part of the transcriptional complex, FLNA^CT can also bind to promoter regions of target genes. Thus, FLNA^CT increases the transactivation function by facilitating translocation to the nucleus and/or nuclear retention and/or by working as a transcriptional coactivator.