Table 2.
Quality of IMiD-based treatment response stratified by CRBN and CUL4A expression. Abbreviations: CR—complete response; VGPR—very good partial response; PR—partial response; SD—stable disease; PD—progressive disease; ORR—overall response rate; p-Value < 0.5 is bolded.
| CRBN(−) n = 60 | CRBN(+) n = 70 | p-Value | CUL4A(−) n = 64 | CUL4A(+) n = 66 | p-Value | |
|---|---|---|---|---|---|---|
| n (%) | n (%) | p = 0.105 | n (%) | n (%) | p = 0.011 | |
| CR | 4 (7) | 7 (10) | 1 (1) | 10 (15) | ||
| VGPR | 8 (13) | 19 (27) | 12 (19) | 15 (23) | ||
| PR | 19 (32) | 25 (36) | 20 (31) | 24 (36) | ||
| SD | 20 (33) | 12 (17) | 19 (30) | 13 (20) | ||
| PD | 9 (15) | 7 (10) | 12 (19) | 4 (6) | ||
| ORR (≥PR) | 31 (52) | 51 (73) | p = 0.0126 | 33 (52) | 49 (74) | p = 0.007 |
| ORR (<PR) | 29 (48) | 19 (27) | 31 (48) | 17 (26) | ||
| ORR (≥VGPR) | 12 (20) | 26 (37) | p = 0.0321 | 13 (20) | 25 (38) | p = 0.027 |
| ORR (<VGPR) | 48 (80) | 44 (63) | 51 (80) | 41 (62) |